Cyprus-Forum.com

[GreekIslandGirl]

Toxicol Appl Pharmacol. 2009 Jan 1;234(1):41-6. Epub 2008 Oct 11.
Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene.
Fujihara J, Fujii Y, Agusa T, Kunito T, Yasuda T, Moritani T, Takeshita H.
Source
Department of Legal Medicine, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan.
Abstract
Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite, and intronic single-nucleotide polymorphisms (SNPs: G7395A, G12390C, T14215C, T35587C, and G35991A) in the AS3MT gene were shown to be related to inter-individual variation in the arsenic metabolism. In the present study, the genotyping for these SNPs was developed using the polymerase chain reaction and restriction fragment length polymorphism technique. Applying this method, the genotype distribution among the Ovambo, Turkish, Mongolian, Korean, and Japanese populations was investigated, and our results were compared with those from other studies. G7395, G12390, T35587, and A35991 were predominant among the five populations in our study. However, a previous study in Argentina, C12390 and G35991 showed the highest allele frequency among the eight populations studied in other studies. The dominant allele of T14215C differed among populations: the T14215 allele was predominant in Argentina, the allele frequency of C14215 was higher than that of T14215 among Turks, Mongolians, Europeans, and American ancestry. In Korea and Japan, similar allele frequencies were observed in T14215 and C14215. Higher allele frequencies were observed in haplotype G7395/G12390/C14215/T35587 with frequencies of 0.40 (Turks), 0.28 (Mongolians), and 0.23 (Koreans). On the other hand, the allele frequency for G7395/G14215/T35587/A35991 was the highest among the Ovambos (0.32), and the frequency for G7395/G12390/C35587/G35991 was the highest among the Japanese (0.27). It is noteworthy that the Japanese haplotype differs from that of the Koreans and Mongolians, which indicates the importance of investigating other intronic polymorphisms in AS3MT, especially in Asians.

[yialousa1971]

What in heaven are you talking about?

He's talking about you.

[denizaksulu]

Neurogenetics. 2009 Jul;10(3):271-3. Epub 2009 Jan 27.
A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype.
Pirkevi C, Lesage S, Condroyer C, Tomiyama H, Hattori N, Ertan S, Brice A, Başak AN.
Source
Molecular Biology and Genetics Department, Neurodegeneration Research Laboratory, Boğaziçi University, 34342 Istanbul, Turkey.
Abstract
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is recognized as the most common cause of familial autosomal dominant and also sporadic forms of Parkinson disease (PD). A common founder has been described for most Europeans and all North Africans and Jews; besides, two distinct G2019S LRRK2 haplotypes were found in a small proportion of European families and in Japanese PD patients. This study revealed a Turkish patient heterozygous for the G2019S mutation sharing the Japanese haplotype. To the best of our knowledge, it is the first time that the G2019S-associated Japanese haplotype has been reported in a different population.

Luvly jubbly. More confusion + Nippon. Very interesting.

[kurupetos]

What in heaven are you talking about?

Heaven? There's no heaven for you ol'boy. Hell is waiting for you.

[B25]

What in heaven are you talking about?

I thought you were an Atheist??? Why do you quote ' heavan'

[GreekIslandGirl]

Neurogenetics. 2009 Jul;10(3):271-3. Epub 2009 Jan 27.
A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype.
Pirkevi C, Lesage S, Condroyer C, Tomiyama H, Hattori N, Ertan S, Brice A, Başak AN.
Source
Molecular Biology and Genetics Department, Neurodegeneration Research Laboratory, Boğaziçi University, 34342 Istanbul, Turkey.
Abstract
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is recognized as the most common cause of familial autosomal dominant and also sporadic forms of Parkinson disease (PD). A common founder has been described for most Europeans and all North Africans and Jews; besides, two distinct G2019S LRRK2 haplotypes were found in a small proportion of European families and in Japanese PD patients. This study revealed a Turkish patient heterozygous for the G2019S mutation sharing the Japanese haplotype. To the best of our knowledge, it is the first time that the G2019S-associated Japanese haplotype has been reported in a different population.

Luvly jubbly. More confusion + Nippon. Very interesting.

Yes, you do get everywhere, doncha?

- Like to see the Turks adopting the old Harakiri custom.

[denizaksulu]

Neurogenetics. 2009 Jul;10(3):271-3. Epub 2009 Jan 27.
A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype.
Pirkevi C, Lesage S, Condroyer C, Tomiyama H, Hattori N, Ertan S, Brice A, Başak AN.
Source
Molecular Biology and Genetics Department, Neurodegeneration Research Laboratory, Boğaziçi University, 34342 Istanbul, Turkey.
Abstract
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is recognized as the most common cause of familial autosomal dominant and also sporadic forms of Parkinson disease (PD). A common founder has been described for most Europeans and all North Africans and Jews; besides, two distinct G2019S LRRK2 haplotypes were found in a small proportion of European families and in Japanese PD patients. This study revealed a Turkish patient heterozygous for the G2019S mutation sharing the Japanese haplotype. To the best of our knowledge, it is the first time that the G2019S-associated Japanese haplotype has been reported in a different population.

Thanks for the well wishes darling.

Luvly jubbly. More confusion + Nippon. Very interesting.

Yes, you do get everywhere, doncha?

- Like to see the Turks adopting the old Harakiri custom.

[kurupetos]

[GreekIslandGirl]

Cat got your tongue, Deniz?

... or is it cheaper to post without words?

[Get Real!]

Who are the Turks?

What baffles me is that some of you are so hell-bent that everything and everyone is Greek… except for the Turks!


How on earth did they escape this “Hellenism” that everyone else alegedly has in abundance in their fridge and free of charge?