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New Down's syndrome blood test, Cypriot Doctor leads team

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New Down's syndrome blood test, Cypriot Doctor leads team

Postby Cap » Tue Jan 18, 2011 10:14 pm

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Postby Oracle » Tue Jan 18, 2011 10:42 pm

Professor Kypros Nicolaides developed the original screen as well.

I expect, and hope, he will be awarded the Nobel Prize for Physiology/Medicine :D
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Postby miltiades » Tue Jan 18, 2011 11:11 pm

A brilliant scientist and one that was born in Paphos to a Greek mother and a Cypriot father , Dr irododos was his father , my older brother was babtised by the good doctor who looked after much of Paphos way back in the 30s 40s and later .
Everyone in Paphos knew the doctor , the father of Kypros , as a good man and a humanitarian .
A week after I was born in may of 1946 I developed pneumonia and was hurriedly babtised at home having been given the last rites
the good doctor arrived from paphos to treat me and here I'm 64 years later.
I take my hat off to this brilliant man and scientist , a dedicated doctor and one that is admired by everyone who meets him .
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Postby Bananiot » Wed Jan 19, 2011 12:19 am

But, Miltiades, he was British trained.
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Postby yialousa1971 » Wed Jan 19, 2011 12:31 am

Bananiot wrote:But, Miltiades, he was British trained.



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Postby Bananiot » Wed Jan 19, 2011 12:58 am

Miltiades, Dr Herodotos used to visit his patients in different villages on horseback. During one such visit, the village fool came for a check and some villagers, in order to tease him, told Herodotos to tell the village fool, in all seriousness, that he was pregnant. So he did and the village fool was really upset. His wife happened to be passing by and he shouted at her. Didn't I tell you not to go on top? Look what you have done now! Kypros told me this some time ago and if you get to see him, remind him of it and give him my regards.
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Postby miltiades » Wed Jan 19, 2011 1:19 am

The village idiot was named Yiannis with the emphasis on the " is " he was not married contrary to some stories , Yiannis was the village idiot in Stroumbi and died a dew days after the 1953 earthquaqe from shock.
Yiannis , commonly known in the village as " Pelloyiannis " was harmless , he adored my father because my father was the only villager that never teased Yiannis and would enlist his help around his village tailor shop .
This story was related to me by my father many times.
Dr irododos babtised many babies in the surrounding villages , my brother later worked at the doctors clinic
and recalls many interesting events. I have the utmost respect for Kypros and maybi also say that he is a true Cypriot and a dedicated scientist , his dedication to his work has unfortunately affected much of his family life .
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Postby Bananiot » Wed Jan 19, 2011 1:33 am

Kypros became very eccentric in the last few years ... a fitting development of a British-trained doctor and researcher. The last time I saw him was in his Wednesday clinic at Harley Street wher he showed me a strange looking black-coloured statue which he told me it depicted Makarios. I said the likeness was stanning, especially after a couple of bottles of wine.
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Postby yialousa1971 » Wed Jan 19, 2011 1:36 am

miltiades wrote:The village idiot was named Yiannis with the emphasis on the " is " he was not married contrary to some stories , Yiannis was the village idiot in Stroumbi and died a dew days after the 1953 earthquaqe from shock.
Yiannis , commonly known in the village as " Pelloyiannis " was harmless , he adored my father because my father was the only villager that never teased Yiannis and would enlist his help around his village tailor shop .
This story was related to me by my father many times.
Dr irododos babtised many babies in the surrounding villages , my brother later worked at the doctors clinic
and recalls many interesting events. I have the utmost respect for Kypros and maybi also say that he is a true Cypriot and a dedicated scientist , his dedication to his work has unfortunately affected much of his family life .


:?
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Postby SKI-preo » Wed Jan 19, 2011 4:53 am

in 2001 he made another diagnostic discovery in ultrasound:
Cypriot doctor's breakthrough on Down's Syndrome detection
By Jennie Matthew
A CYPRIOT foetal expert, Professor Kypros Nicolaides, has made a potential breakthrough that could make the identification of babies at high-risk from Down's Syndrome 97 per cent reliable.

Initial research conducted over a six-month period suggests that 75 per cent of embryos without a visible nasal bone at 12-weeks have Down's Syndrome.

Nicolaides made the observation based on the ultrasounds of 700 babies at King's College Hospital in London.

His findings will be published in The Lancetmedical journal in a few weeks' time.

He then hopes to pioneer an international study based on 20,000 women from all over the world to prove his initial finding, before the examination makes its way onto the hospital ward.

The British Medical Journalconsiders the 12-week nuchal translucency test - developed by Nicolaides in 1992 - plus ultrasound, the most effective way of predicting whether unborn babies are at high-risk from Down's Syndrome.

The current tests are 90 per cent accurate in determining whether a foetus is at high-risk from Down's.

Foetuses grouped in this category are then subject to an amniocentesis for a definite diagnosis, a test that carries a very high risk of miscarriage.

Minimising the percentage of women that go for further tests would reduce the number of miscarriages, which kill healthy foetuses.

Ioannis Kallikas, gynaecologist at the Makarios Hospital in Nicosia and close associate of Nicolaides, said that, if proved right, the nasal examination would be incorporated with the current 12-week tests.

" If the nasal bone is incorporated with the current 12 weeks tests, then it could mean that doctors can predict downs 95 to 97 per cent successfully. So on a gross level, this observation improves that by another 10 per cent,"he said.

Nicolaides told the Cyprus Mailthat he made the breakthrough based on the simple observation that Down's children have flat faces and small noses.

Research shows that normal foetuses tend to develop an identifiable nasal bone at 11 weeks. Given a delay in the ossification of the cartilage, Down's babies don't do so until 16 or 18 weeks.

Therefore, an ultrasound at 12 weeks can be a crucial determinant.

" I started on the nasal bones then it was incredible,"said Nicolaides.

His nuclear translucency scan was developed 10 years ago, after reading a description of Down's babies written by a London doctor in 1860 - remarking that they have a short, thick neck.

Nicolaides was born in Paphos in 1953. He is director of the Harris Birthright Research Centre for Foetal Medicine at King's College, where he heads a team of 30 doctors.

In 1999, he was conferred the Ian Donald Gold Medal from the International Society of Ultrasound in Obstetrics and Gynaecology.

Copyright Cyprus Mail 2001
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