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Health supplement statusThe extract of bitter orange (and bitter orange peel) has been used in dietary supplements as an aid to fat loss and as an appetite suppressant, although in traditional Chinese medicine it is always prescribed in concert with other support herbs, not in isolation. Bitter orange contains synephrine, a substance similar to ephedrine, which acts on the α1 adrenergic receptor to constrict blood vessels and increase blood pressure and heart rate.
Following bans on the herbal stimulant ephedra in the U.S., Canada, and elsewhere, bitter orange has been substituted into "ephedra-free" herbal weight-loss products by dietary supplement manufacturers.While bitter orange has not undergone formal safety testing, it can cause the same spectrum of adverse events as ephedra.Case reports have linked bitter orange supplements to strokes, angin and ischemic colitis.
The National Center for Complementary and Alternative Medicine found that "there is currently little evidence that bitter orange is safer to use than ephedra." There is no evidence that bitter orange is effective in promoting weight loss.
http://en.wikipedia.org/wiki/Bitter_ora ... ent_status